used after optimizing the crystallizer, indicating the negative impact of adding pure solvent to the process (reduced concentration via dilution, and decreased residence time) outweighs the positive benefits of dissolving fines. Bradley James Ridder, get fast, free shipping with Amazon Prime. Abstract, we have investigated the simulation-based, steady-state optimization of a new type of crystallizer for the production of pharmaceuticals.
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Bradley Ridder holds a PhD in chemical engineering from Purdue University, West.
Articles on pharmaceutical crystallization, and his master s thesis was in the.
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Fine crystals are a known processing difficulty in drug manufacture, thus motivating the development of a process that can eliminate them efficiently. The multi-segment, multi-addition plug-flow crystallizer (msma-PFC) offers better control over supersaturation in one dimension compared to a batch or stirred-tank crystallizer. We conclude that the success observed in hitting the target distribution has more to do with using multiple segments and having finer control over supersaturation than with the ability to go below solubility. Prior results for cooling crystallization indicated this to be possible. Prime members enjoy free Two-Day Shipping and exclusive access to music, movies, TV shows, original audio series, and Kindle books. We have lastly performed a parametric study on the use of the msma-PFC for in-situ dissolution of fine crystals back into solution. Our results showed that excessive nucleation still overwhelms the msma-PFC for in-situ fines dissolution when nucleation is too high.